The combined administration of daniplestim and mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression

This study evaluated the ability of daniplestim, a high affinity interleukin 3 receptor agonist, to enhance the hematopoietic response of Mpl ligand (Mpl‐L) administration in nonhuman primates following severe, radiation‐induced myelosuppression. Rhesus monkeys were total body x‐irradiated (TBI) to...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 1998, Vol.16 (S1), p.143-154
Hauptverfasser:	Farese, Ann M., Macvittie, Thomas J., Lind, Lisa B., Smith, Walter G., Mckearn, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Blood Transfusion Bone Marrow - drug effects Bone Marrow - metabolism Bone Marrow - radiation effects Cricetinae Cytokines - metabolism Cytokines - pharmacology Daniplestim Disease Models, Animal Drug Combinations Drug Interactions - physiology Hematopoiesis - drug effects Hematopoiesis - physiology Hematopoiesis - radiation effects Immunosuppression - methods Interleukin-3 Macaca mulatta Male Mpl‐L Myelosuppression Neutropenia - drug therapy Neutropenia - physiopathology Peptide Fragments Peptides - pharmacology Primate Radiation Recovery of Function - drug effects Recovery of Function - physiology Thrombocytopenia Thrombocytopenia - drug therapy Thrombocytopenia - physiopathology Thrombopoietin - metabolism Thrombopoietin - pharmacokinetics Time Factors
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