The combined administration of daniplestim and mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression

This study evaluated the ability of daniplestim, a high affinity interleukin 3 receptor agonist, to enhance the hematopoietic response of Mpl ligand (Mpl‐L) administration in nonhuman primates following severe, radiation‐induced myelosuppression. Rhesus monkeys were total body x‐irradiated (TBI) to 600 cGy, midline tissue dose. Beginning on day 1 post‐TBI, animals were s. c. administered daniplestim (100 μg/kg bid; n = 4), Mpl‐L (10 μg/kg qd; n = 3), daniplestim (100 μg/kg bid) plus Mpl‐L (10 μg/kg qd) (n = 4) or 0.1% autologous serum (AS) (n = 11) for 18 days. CBCs were monitored for 60 d after TBI. The duration of thrombocytopenia (platelet count; PLT