Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA

Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA

mRNA Delivery In article number 2200071, Kazuki Hashiba, Yusuke Sato, and co‐workers investigate the impact of branched ionizable lipids on lipid‐nanoparticle‐based mRNA delivery. Systematic examination of the chemical structures of branched ionizable lipids reveals that branched structures play imp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Small science 2023-01, Vol.3 (1), p.n/a
Hauptverfasser: Hashiba, Kazuki, Sato, Yusuke, Taguchi, Masamitsu, Sakamoto, Sachiko, Otsu, Ayaka, Maeda, Yoshiki, Shishido, Takuya, Murakawa, Masao, Okazaki, Arimichi, Harashima, Hideyoshi
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:mRNA Delivery In article number 2200071, Kazuki Hashiba, Yusuke Sato, and co‐workers investigate the impact of branched ionizable lipids on lipid‐nanoparticle‐based mRNA delivery. Systematic examination of the chemical structures of branched ionizable lipids reveals that branched structures play important roles in endosomal escape via membrane fusion and in delivery of exogenous mRNAs to the cytoplasm to be translated.
ISSN:2688-4046
2688-4046
DOI:10.1002/smsc.202370001