Microfluidic Impedance‐Deformability Cytometry for Label‐Free Single Neutrophil Mechanophenotyping (Small 18/2022)

Neutrophil Mechanophenotyping The intrinsic biophysical states of neutrophils are often associated with immune dysfunctions. In article number 2104822, Han Wei Hou and co‐workers report an “optics‐free” microfluidic biophysical cytometer for impedance‐based single cell electro‐mechano‐phenotyping. T...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-05, Vol.18 (18), p.n/a
Hauptverfasser:	Petchakup, Chayakorn, Yang, Haoning, Gong, Lingyan, He, Linwei, Tay, Hui Min, Dalan, Rinkoo, Chung, Aram J., Li, King Ho Holden, Hou, Han Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	biophysical phenotyping impedance cytometry neutrophil profiling
Online-Zugang:	Volltext
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Zusammenfassung:	Neutrophil Mechanophenotyping The intrinsic biophysical states of neutrophils are often associated with immune dysfunctions. In article number 2104822, Han Wei Hou and co‐workers report an “optics‐free” microfluidic biophysical cytometer for impedance‐based single cell electro‐mechano‐phenotyping. The developed platform integrates elasto‐inertial focusing, hydrodynamic cell pinching, and multifrequency differential impedance sensing to enable label‐free and multi‐parametric neutrophil profiling towards rapid clinical diagnostics.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.202270093