Organ‐On‐A‐Chip: Biomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model (Small 15/2017)

Organ‐On‐A‐Chip: Biomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model (Small 15/2017)

A progeria‐on‐a‐chip is developed to recapitulate the biomechanical dynamics of vascular disease and aging, shown in article number 1603737, by Lino Ferreira, Ali Khademhosseini, and co‐workers. The model stretches vascular smooth muscle cells and shows an exacerbated inflammation and DNA damage. Th...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2017-04, Vol.13 (15), p.n/a
Hauptverfasser: Ribas, João, Zhang, Yu Shrike, Pitrez, Patrícia R., Leijten, Jeroen, Miscuglio, Mario, Rouwkema, Jeroen, Dokmeci, Mehmet Remzi, Nissan, Xavier, Ferreira, Lino, Khademhosseini, Ali
Format: Artikel
Sprache:eng
Schlagworte:
aging
mechanotransduction
organ‐on‐a‐chip
progeria
vascular disease
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Zusammenfassung:A progeria‐on‐a‐chip is developed to recapitulate the biomechanical dynamics of vascular disease and aging, shown in article number 1603737, by Lino Ferreira, Ali Khademhosseini, and co‐workers. The model stretches vascular smooth muscle cells and shows an exacerbated inflammation and DNA damage. The progeria‐on‐a‐chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201770087