Structural Modulation of Chitosan/Polyacrylic Acid‐based Hydrogels for Optimized Controlled Drug Release Performance

A pH‐sensitive semi‐interpenetrating network hydrogel was synthesised by free radical polymerization using a one‐pot method using chitosan (CS) and alanine (AA) as the raw materials, and then the hydrogel was immersed in a solution of the model drug aspirin (Asa) for loading, and subsequently used for drug sustained‐release testing. The effects of the ratio of CS and AA on the internal structure of hydrogels were investigated, and the mechanism of CS/PAA semi‐interpenetrating network hydrogels upon drug slow release was explored. The results showed that increasing the composite ratio of PAA resulted in a subsequent increase in the drug loading capacity of CS/PAA hydrogels and the cumulative release of drugs. When the concentration of the drug‐loading solution was 200 mg/L, the drug loading and encapsulation efficiency of CS/PAA‐1 were 16.23±0.57 (%) and 72.16±3.84 (%), respectively (p