Synthesis of New Indole‐Based Thiazole Derivatives as Potential Antiglycation and Anti α‐Glucosidase Agents: In Vitro and In Silico Studies

Diabetes mellitus is a metabolic disease, characterized by the elevated levels of blood glucose, known as hyperglycemia. It is one of the serious health challenges, and is rapidly becoming a significant cause of morbidity, and mortality, worldwide. The persistent hyperglycemic state in diabetes mellitus leads to the formation of advanced glycation end products (AGEs), which is identified as a key factor involved in the progression of diabetes, and diabetes‐associated late complications. keeping in view the medicinal properties of indole, and thiazole, in the present study, novel indole‐based thiazoles (1–26) were synthesized, and evaluated for their in vitro α‐glucosidase, and antiglycation activities. These indole‐based thiazoles were characterized from their spectral data. All these compounds showed moderate to excellent antiglycation activity (IC50 between 642.2±0.013 to 46.93±0.003 μM) including compounds 17, 20, 22–26 which showed a significant antiglycation activity as the reference molecule, rutin (IC50=56±0.008 μM) used as standard. Further, these derivatives exhibited significant α‐glucosidase inhibition activity (P