A Carbon Ionic Liquid Paste Sensor Modified with Lanthanum Nanorods /MWCNTs/Nafion Hybrid Composite for Carbamazepine Screening in Biological and Pharmaceutical Media

In this original paper, a new electrochemical sensor for carbamazepine (CBZ) was developed. First, lanthanum nanorods (LaNRs) were synthesized by a simple microemulsion method. Then, a nanocomposite consist of lanthanum nanorods, multiwalled carbon nanotubes (MWCNTs), and nafion (LaNRs/MWCNTs/Nafion) was prepared and deposited at the surface of the carbon ionic liquid paste electrode (CILPE). X‐ray diffraction (XRD), transmission electron microscopy (TEM), energy dispersion spectroscopy (EDS), and scanning electron microscopy (SEM) were used to characterize the structure of synthesized LaNRs and the surface morphology of the modified electrode. Also, electrochemical methods such as cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) were utilized to investigate the performance of the proposed electrode. Under the optimal conditions, a linear relationship of the electrical signal versus the concentration of CBZ was obtained in the range from 0.06 μM to 20 μM with a detection limit (LOD) of 0.006 μM and quantification limit (LOQ) of 0.02 μM. Eventually, the fabricated sensor was satisfactorily applied for rapid and accurate determination of CBZ in real samples. In this research work, a carbon ionic liquid paste electrode (CILPE) based on butyl‐3‐methylimidazolium bis (trifluoromethylsulfonyl) imide ([bmim] NTF2) was fabricated and further modified with lanthanum nanorods / carbon nanotubes (LaNRs/CNTs) hybrid composite by a simple casting method. The modified electrode was used for measurement of carbamazepine (CBZ) with an excellent electrochemical catalytic behavior. The application of the electrode was investigated by cyclic voltammetry and square wave voltammetry. The proposed sensor was successfully applied for the determination of CBZ in tablet and urine samples.