Remarkably Boosted Molecular Delivery Triggered by Combined Thermal and Flexoelectrical Field Dual Stimuli

Efficient controllable drug delivery is important in medical treatment. Abrupt release of a drug is important in targeted drug release therapies or first‐aid scenarios but materials reported to date still suffer from low efficiencies with regards to both release speeds and the total released amount. In this study, we report that combining both thermal and flexoelectrical field stimuli can lead to effective acceleration of drug delivery. When tapping the flexible substrate elevated temperatures, acceleration of drug release is increased from up to 21 % to 540 % times for different molecules, remarkably higher than a single type of thermal or E‐field stimulus. In addition, the dual responsive substrate exhibits good antibacterial effects. We believe that the work reported herein will be of benefit to the design of rapid drug release materials for medical treatment. We designed an LBL‐based strategy for the preparation of delivery materials that rapidly release molecules in response to dual stimuli. Studies using various charged model molecules indicated that either flexoelectricity triggered by hand tapping or a rise in temperature effectively promotes molecular release. In addition, the dual responsive substrate exhibits good antibacterial effects. We believe that the work reported herein will be of benefit to the design of rapid drug release materials for medical treatment.