Microwave‐Assisted Synthesis of Positional Isomeric Dihydro‐triazolo‐pyrimido‐acridines and Biological studies

Microwave synthetic methodologies were proposed for the preparation of positional isomeric dihydro‐triazolo‐pyrimido‐acridines, 3 a‐j and 9 a‐h via friedlander synthesis using response surface methodology (RSM). The advantages of these methodologies over conventional methods are it provides good yields with short reaction times. Free radical scavenging and antifungal studies were performed for compounds 3 a‐j and 9 a‐h. The results of antioxidant assay revealed that compounds 3 c, 3 d and 9 b exhibited excellent property whereas compounds 3 a and 9 a showed significant antifungal property against Aspergillus flavus (A.flavus) and Aspergillus niger (A. niger). Microwave methodology was adopted to prepare positional isomeric dihydro‐triazolo‐pyrimido‐acridines. RSM was used to find the theoretical yield of the product by varying parameters. Antioxidant and antifungal study were screened for the synthesized compounds.