Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents

An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been...

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Veröffentlicht in:ChemistrySelect (Weinheim) 2019-08, Vol.4 (31), p.9190-9193
Hauptverfasser: Kamal, Raj, Kumar, Vipan, Kumar, Ravinder, Kumar, Vikas, Sharma, Prabodh C., Bansal, Kushal K.
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container_end_page 9193
container_issue 31
container_start_page 9190
container_title ChemistrySelect (Weinheim)
container_volume 4
creator Kamal, Raj
Kumar, Vipan
Kumar, Ravinder
Kumar, Vikas
Sharma, Prabodh C.
Bansal, Kushal K.
description An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been accomplished. Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents. Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. Synthesized fused heterocyclic hydrids bearing medicinally important 1,2,4‐triazolyl, benzothiazolyl and pyrazolyl moieties were evaluated for their anti‐infective potential.
doi_str_mv 10.1002/slct.201901312
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Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents. Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. 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subjects 1,2,4-Triazole
Anthelmintic
Antibacterial
Chloramine-T
Oxidative cyclization
title Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents
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