Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents
An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been...
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Veröffentlicht in: | ChemistrySelect (Weinheim) 2019-08, Vol.4 (31), p.9190-9193 |
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creator | Kamal, Raj Kumar, Vipan Kumar, Ravinder Kumar, Vikas Sharma, Prabodh C. Bansal, Kushal K. |
description | An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been accomplished. Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents.
Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. Synthesized fused heterocyclic hydrids bearing medicinally important 1,2,4‐triazolyl, benzothiazolyl and pyrazolyl moieties were evaluated for their anti‐infective potential. |
doi_str_mv | 10.1002/slct.201901312 |
format | Article |
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Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. Synthesized fused heterocyclic hydrids bearing medicinally important 1,2,4‐triazolyl, benzothiazolyl and pyrazolyl moieties were evaluated for their anti‐infective potential.</description><identifier>ISSN: 2365-6549</identifier><identifier>EISSN: 2365-6549</identifier><identifier>DOI: 10.1002/slct.201901312</identifier><language>eng</language><subject>1,2,4-Triazole ; Anthelmintic ; Antibacterial ; Chloramine-T ; Oxidative cyclization</subject><ispartof>ChemistrySelect (Weinheim), 2019-08, Vol.4 (31), p.9190-9193</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2892-482eaf25822ccd6c51dbe070416461fb1898f6c2c72d9135031d622d7342bf3d3</citedby><cites>FETCH-LOGICAL-c2892-482eaf25822ccd6c51dbe070416461fb1898f6c2c72d9135031d622d7342bf3d3</cites><orcidid>0000-0002-9403-584X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fslct.201901312$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fslct.201901312$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Kamal, Raj</creatorcontrib><creatorcontrib>Kumar, Vipan</creatorcontrib><creatorcontrib>Kumar, Ravinder</creatorcontrib><creatorcontrib>Kumar, Vikas</creatorcontrib><creatorcontrib>Sharma, Prabodh C.</creatorcontrib><creatorcontrib>Bansal, Kushal K.</creatorcontrib><title>Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents</title><title>ChemistrySelect (Weinheim)</title><description>An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been accomplished. Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents.
Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. Synthesized fused heterocyclic hydrids bearing medicinally important 1,2,4‐triazolyl, benzothiazolyl and pyrazolyl moieties were evaluated for their anti‐infective potential.</description><subject>1,2,4-Triazole</subject><subject>Anthelmintic</subject><subject>Antibacterial</subject><subject>Chloramine-T</subject><subject>Oxidative cyclization</subject><issn>2365-6549</issn><issn>2365-6549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkE1OwzAQRi0EElXplrUvkGJPEidZVhGllYpaibKOHP9Qo9RBtgVKxYIjcEZOQkIRsGM134zmfYuH0CUlU0oIXPlGhCkQWhAaUzhBI4hZGrE0KU7_5HM08f6REEJZziDNRui13DWt43tj1cfb-xbfKml4UBLPuTCNwmur8KYN-K6zYae88bjVeNM5fmibrgnODKGtlT20Yfe1KLzoamekx9wPqLIBz2wwff3SaiWCeVZ49tCf_QU607zxavI9x-h-fr0tF9FqfbMsZ6tIQF5AlOSguIY0BxBCMpFSWSuSkYSyhFFd07zINRMgMpAFjVMSU8kAZBYnUOtYxmM0PfYK13rvlK6enNlz11WUVIO-atBX_ejrgeIIvPQOun--q7tVuf1lPwHvVHg9</recordid><startdate>20190823</startdate><enddate>20190823</enddate><creator>Kamal, Raj</creator><creator>Kumar, Vipan</creator><creator>Kumar, Ravinder</creator><creator>Kumar, Vikas</creator><creator>Sharma, Prabodh C.</creator><creator>Bansal, Kushal K.</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9403-584X</orcidid></search><sort><creationdate>20190823</creationdate><title>Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents</title><author>Kamal, Raj ; Kumar, Vipan ; Kumar, Ravinder ; Kumar, Vikas ; Sharma, Prabodh C. ; Bansal, Kushal K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2892-482eaf25822ccd6c51dbe070416461fb1898f6c2c72d9135031d622d7342bf3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>1,2,4-Triazole</topic><topic>Anthelmintic</topic><topic>Antibacterial</topic><topic>Chloramine-T</topic><topic>Oxidative cyclization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamal, Raj</creatorcontrib><creatorcontrib>Kumar, Vipan</creatorcontrib><creatorcontrib>Kumar, Ravinder</creatorcontrib><creatorcontrib>Kumar, Vikas</creatorcontrib><creatorcontrib>Sharma, Prabodh C.</creatorcontrib><creatorcontrib>Bansal, Kushal K.</creatorcontrib><collection>CrossRef</collection><jtitle>ChemistrySelect (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamal, Raj</au><au>Kumar, Vipan</au><au>Kumar, Ravinder</au><au>Kumar, Vikas</au><au>Sharma, Prabodh C.</au><au>Bansal, Kushal K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents</atitle><jtitle>ChemistrySelect (Weinheim)</jtitle><date>2019-08-23</date><risdate>2019</risdate><volume>4</volume><issue>31</issue><spage>9190</spage><epage>9193</epage><pages>9190-9193</pages><issn>2365-6549</issn><eissn>2365-6549</eissn><abstract>An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been accomplished. Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents.
Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. Synthesized fused heterocyclic hydrids bearing medicinally important 1,2,4‐triazolyl, benzothiazolyl and pyrazolyl moieties were evaluated for their anti‐infective potential.</abstract><doi>10.1002/slct.201901312</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9403-584X</orcidid></addata></record> |
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subjects | 1,2,4-Triazole Anthelmintic Antibacterial Chloramine-T Oxidative cyclization |
title | Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents |
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