Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents

An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been accomplished. Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents. Environmentally benign chloramines‐T mediated oxidative cyclizations of in situ formed N‐heteroarylhydrazones were accomplished to afford 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐b]‐1,3‐benzothiazoles. Synthesized fused heterocyclic hydrids bearing medicinally important 1,2,4‐triazolyl, benzothiazolyl and pyrazolyl moieties were evaluated for their anti‐infective potential.