Enantioselective Syntheses of Axially Chiral Phosphonates or Phosphine Oxides via Asymmetric Suzuki Reactions with Chiral Sulfinamide Monophosphine Ligands

A class of chiral sulfinamide monophosphine ligands Ming‐Phos were firstly employed in the asymmetric Suzuki coupling reactions. Using the in‐situ formed catalyst from PdCl2 and (R, SS)‐M07, 22 axially chiral phosphonates or phosphine oxides were successfully synthesized in 29−99% yields with up to 98% ee. This method provides a simple and efficient protocol for the synthesis of axially chiral biaryl monophosphine oxides. A class of chiral sulfinamide monophosphine ligands Ming‐Phos were employed in asymmetric Suzuki coupling reaction. Multiple axially chiral phosphonates or phosphine oxides were successfully synthesized in 29−99% yields with 68−98% ees.