MgO‐Nanoparticle‐Catalyzed Synthesis and Evaluation of Antimicrobial and Antioxidant Activity of New Multi‐Ring Compounds Containing Spiro[indoline‐3,4′‐[1,3]dithiine]

Multi‐component reaction indoline‐2,3‐dione derivatives, malononitrile, carbon disulfide and dimedone have led to newly synthesized 6′‐amino‐2′‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐2‐oxospiro[indoline‐3,4′‐[1,3]dithiine]‐5′‐carbonitrile derivatives under acidic and base conditions with high efficiency during a simplified process. In acidic conditions, using MgO nanoparticleas as a catalyst, greater yields in shorter time was observed. The biological effects of synthetic derivatives such as antibacterial and antifungal effects based on inhibition zone diameter, minimum inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration and antioxidant effects on DPPH free radical, have been the subject of previous studies. The results showed that some derivatives show higher antimicrobial effects compared to commercial drugs. In this study, six new derivatives of 6′‐amino‐2′‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐2‐oxospiro[indoline‐3,4′‐[1,3]dithiine]‐5′‐carbonitrile in two ways were synthesized. The use of MgO nanoparticles showed high efficiency and reduced time in the synthesis of compounds. Biological properties including antibacterial, antifungal and antioxidant from synthetic compounds were investigated and good results were obtained from the compounds and acceptable relation between the structure of the compounds and its biological properties was found.