RuCl 3 / PPh 3 ‐ Catalyzed Direct Conversion of Isoxazol‐5‐ones to 2,3‐Disubstituted Pyridines

RuCl 3 / PPh 3 ‐ Catalyzed Direct Conversion of Isoxazol‐5‐ones to 2,3‐Disubstituted Pyridines

A novel catalytic system employing RuCl 3 / PPh 3 is described for the preparation of 2,3‐disubstituted pyridines starting from 3,4‐disubstituted isoxazol‐5‐ones and acrolein. Mechanistic studies involving 31 P NMR, HRMS analyses and control experiments have been performed in order to support key ev...

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Veröffentlicht in:ChemistrySelect (Weinheim) 2019-03, Vol.4 (12), p.3360-3365
Hauptverfasser: Fernandes, Alessandra A. G., Stivanin, Mateus L., Jurberg, Igor D.
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel catalytic system employing RuCl 3 / PPh 3 is described for the preparation of 2,3‐disubstituted pyridines starting from 3,4‐disubstituted isoxazol‐5‐ones and acrolein. Mechanistic studies involving 31 P NMR, HRMS analyses and control experiments have been performed in order to support key events and intermediates proposed for this transformation.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201900761