Regioselective Synthesis, Molecular Descriptors of (1,5‐Disubstituted 1,2,3‐Triazolyl)Coumarin/Quinolone Derivatives and Their Docking Studies against Cancer Targets

A series of (1,5‐disubstituted 1,2,3‐triazolyl)coumarin/quinolone derivatives (tcd and tqd) have been synthesized in good to excellent yields via Ag2O NPs catalyzed azide‐alkyne cycloaddition reactions. We then tested the drug‐likeness of tcd and tqd by analyzing molecular descriptors. Rational drug design showed that these derivatives indeed are potential anticancer agents against tankyrases. A series of (1,5‐disubstituted 1,2,3‐triazolyl)coumarin/quinolone derivatives (tcd and tqd) have been synthesized in good to excellent yields via Ag2O NPs catalyzed azide‐alkyne cycloaddition reactions. We then tested the drug‐likeness of tcd and tqd by analyzing molecular descriptors. Rational drug design showed that these derivatives indeed are potential anti‐cancer agents against tankyrases.