Cinchona Alkaloids in the Synthesis of Chiral Salts of Phosphorus Dithioacids on the Basis of 1,2:3,4‐Di‐O‐isopropylidene‐α‐D‐galactopyranose

Optically active dithiophosphoric and dithiophosphonic acids were obtained by the reactions of 1,2:3,4‐di‐O‐isopropylidene‐α‐D‐galactopyranose with tetraphosphorus decasulfide or Lawesson's reagent respectively. The reactions of dithiophosphoric and dithiophosphonic acids with 8 S,9R‐quinine, 8R,9 S‐quinidine, 8 S,9R‐cinchonidine, 8R,9 S‐cinchonine, and 8R,9 S‐hydroquinidine result in chiral salts of dithiophosphoric and dithiophosphonic acids. Antimicrobial activity of products obtained was tested. Optically active dithiophosphoric and dithiophosphonic acids were obtained by the reactions of 1,2:3,4‐di‐O‐isopropylidene‐α‐D‐galactopyranose with tetraphosphorus decasulfide or Lawesson's reagent respectively. The reactions of dithiophosphoric and dithiophosphonic acids with 8 S,9R‐quinine, 8R,9 S‐quinidine, 8 S,9R‐cinchonidine, 8R,9 S‐cinchonine, and 8R,9 S‐hydroquinidine result in chiral salts of dithiophosphoric and dithiophosphonic acids possessed antimicrobial activity.