Synthesis of Indole‐2‐methylsulfonamides by Domino Sonogashira Coupling and Hydroamination Reaction
A domino Sonogashira coupling and hydroamination reaction between o‐iodo‐N,N‐dimethylaniline derivatives and propargyl sulfonamides are described. This protocol allows access to a variety of indole‐2‐methylsulfonamides in good to excellent yields. The structures of the synthesized compounds are conf...
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| Veröffentlicht in: | ChemistrySelect (Weinheim) 2017-04, Vol.2 (10), p.3147-3151 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A domino Sonogashira coupling and hydroamination reaction between o‐iodo‐N,N‐dimethylaniline derivatives and propargyl sulfonamides are described. This protocol allows access to a variety of indole‐2‐methylsulfonamides in good to excellent yields. The structures of the synthesized compounds are confirmed by XRD studies.
A domino Sonogashira coupling and hydroamination reaction for the synthesis of indole‐2‐methylsulfonamides in good to excellent yields |
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| ISSN: | 2365-6549 2365-6549 |
| DOI: | 10.1002/slct.201700544 |