Bismuth Nitrate Catalyzed One‐Pot Multicomponent Synthesis of a Novel Series of Diversely Substituted 1,8‐Dioxodecahydroacridines at Room Temperature

A simple, straightforward, and convenient one‐pot synthesis of a new series of diversely substituted 1,8‐dioxodecahydroacridines (5a–q and 5′a–g), particularly bearing varying amino acids as part of the building block, has been developed based on a low‐cost and environmentally benign Bi(NO3)3.5H2O catalyst via pseudo‐four component reactions of 1,3‐cyclohexanediones (1/4), various primary amines (2) and aldehydes (3) in ethanol at ambient temperature (25‐30 oC). High atom‐economy, good to excellent yields, eco‐friendliness, and mild reaction conditions are some of the important features of this protocol. Old is gold: Bi(NO3)3.5H2O, a low‐cost and environmentally benign metal salt, has further been explored as an efficient catalyst for the straightforward and convenient one‐pot synthesis of a new series of diversely substituted 1,8‐dioxodecahydroacridines (5a–q and 5′a–g), particularly bearing varying amino acids as part of the building block, in ethanol at ambient temperature. High atom‐economy, good to excellent yields, eco‐friendliness, and mild reaction conditions are some of the important features of this protocol.