One‐Step Synthesis of Fused Chromeno[4,3‐b]pyrrolo[3,2‐h]quinolin‐7(1H)‐One Compounds and their Anticancer Activity Evaluation

FeCl3 catalyzed synthesis of chromeno[4,3‐b]pyrrolo[3,2‐h]quinolin‐7(1H)‐one compounds is reported in this paper. The target molecules were synthesized by combining 4‐hydroxy coumarin, 7‐ amino indole and diverse aromatic aldehydes in 1,4‐dioxane as a solvent, at 90 °C. The final compounds obtained were subjected to anticancer activity evaluation using murine melanoma cell lines (B16F10). Best result was obtained for compound bearing 2‐chloro‐3‐pyridyl substituent, which showed IC50 value of 70.74 μM. Concise synthesis of fused chromeno[4,3‐b]pyrrolo[3,2‐h]quinolin‐7(1H)‐one compounds by easily available starting materials and their anticancer activity evaluation against murine melanoma cell lines.