Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

A photoionization hydrogen laser time‐of‐flight mass spectrometer system (H2‐TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2‐TOFMS showed primarily intact mole...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Rapid communications in mass spectrometry 2005-01, Vol.19 (1), p.15-22
Hauptverfasser:	Finch, Jeffrey W., Toerne, Kevin A., Schram, Karl H., Denton, M. Bonner
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - urine Humans Lasers Mass Spectrometry - methods Pharmaceutical Preparations - chemistry Spectrometry, Mass, Electrospray Ionization - methods Spectrophotometry, Ultraviolet - methods Substance-Related Disorders
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A photoionization hydrogen laser time‐of‐flight mass spectrometer system (H2‐TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2‐TOFMS showed primarily intact molecular ions (M+.) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid‐phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents. Copyright © 2004 John Wiley & Sons, Ltd.
ISSN:	0951-4198 1097-0231
DOI:	10.1002/rcm.1742