Mass spectrometry of cyanocobalamine, glucose and raffinose in the solid state and on a disperse oxide surface

The biologically active systems were synthesized by adsorption of vitamin B12, glucose and raffinose on an ultrafine oxide surface and studied by means of thermal analysis and temperature‐programmed mass spectrometry. It is shown that adsorption of cyanocobalamine (B12) on the silica surface transformed the propionamide group to a weakly bound form. The role of the charged cobalt atom and of the propionamide and benzimide groups in the adsorption mechanism is discussed. Experimental data were obtained confirming the stable adsorption of glucose and raffinose on an ultrafine pyrogenic silica surface modified by amino groups.