Investigation of the metabolism of felodipine using on-line liquid chromatography/UV diode array detection/atmospheric pressure chemical ionization mass spectrometry as a diagnostic tool

The utility of on‐line liquid chromatogaphy coupled to UV diode array detection and atmospheric pressure chemical ionization mass spectrometry for the analysis of microsomal metabolites of felodipine has been investigated. A previously unreported metabolite of felodipine, extracted from male rat mic...

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Veröffentlicht in:Rapid communications in mass spectrometry 1993-07, Vol.7 (7), p.605-609
Hauptverfasser: Macrae, P. V., Jones, B. C., Todd, J. F. J.
Format: Artikel
Sprache:eng
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Zusammenfassung:The utility of on‐line liquid chromatogaphy coupled to UV diode array detection and atmospheric pressure chemical ionization mass spectrometry for the analysis of microsomal metabolites of felodipine has been investigated. A previously unreported metabolite of felodipine, extracted from male rat microsomes, has been detected using this technique. UV diode array detection has been used to characterize this metabolite as a dihydropyridine metabolite and tandem mass spectrometry data used to assign a structure.
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.1290070710