Production of Small Libraries Optimising and Examining the Scope of Aqueous Acceleration of the Passerini Reaction

It has been reported that the rate of the Passerini reaction is accelerated in water or in a mixture of water and an organic solvent. Here, the synthesis of small libraries using the Passerini reaction in a biphasic system is described. Examination of the effects of stoichiometry and different reagents demonstrated the ability to produce material of high purity without chromatography, within a specified structural scope.