Inhibitory effects of echinoisoflavanone and sophoraisoflavanone D in Sophora chrysophylla SEEM on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro

We present the results of an in vitro investigation of the inhibitory effects of echinoisoflavanone and sophoraisoflavanone D isolated from Sophora chrysophylla SEEM on copper‐induced protein oxidative modification of mouse brain homogenate in vitro. They inhibited copper‐induced protein oxidative modification. The order of inhibitory effects of these isoflavanones and mannitol as a hydroxyl radical scavenger was sophoraisoflavanone D > mannitol > echinoisoflavanone. The results suggest that these natural products may be of use in cases where oxidative stress is present. Copyright © 2002 John Wiley & Sons, Ltd.