Therapeutic Effect of Supercritical CO 2 Extracts of Curcuma Species with Cancer Drugs in Rhabdomyosarcoma Cell Lines
Synergistic effect of supercritical CO 2 extracts of Curcuma species with conventional chemotherapeutic drugs was investigated in human alveolar (SJRH30) and embryonal (RD) rhabdomyosarcoma cell lines. The Curcuma amada (mango ginger) (CA) extract showed the highest levels of cytotoxicity with inhib...
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| Veröffentlicht in: | Phytotherapy research 2015-08, Vol.29 (8), p.1152-1160 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Synergistic effect of supercritical CO
2
extracts of
Curcuma
species with conventional chemotherapeutic drugs was investigated in human alveolar (SJRH30) and embryonal (RD) rhabdomyosarcoma cell lines. The
Curcuma amada
(mango ginger) (CA) extract showed the highest levels of cytotoxicity with inhibitory concentration IC
50
values of 7.133 µg/ml and 7.501 µg/ml for SJRH30 and RD cell lines, respectively, as compared with
Curcuma longa
(turmeric) and
Curcuma xanthorrhiza
(Javanese turmeric) extracts. CA showed synergistic cytotoxic effects with vinblastine (VBL) and cyclophosphamide (CP) as indicated by the combination index values of |
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| ISSN: | 0951-418X 1099-1573 |
| DOI: | 10.1002/ptr.5360 |