Isolation of Diacyl Glycerol Acyl Transferase (DGAT) Inhibitors from Pachydictyon coriaceum

The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenul...

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Veröffentlicht in:	Phytotherapy research 2011-07, Vol.25 (7), p.1041-1045
Hauptverfasser:	Choi, Byoung Wook, Lee, Hyun Sun, Lee, Kyung Bok, Lee, Bong Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl CoA:diacylglycerol acyltransferase (DGAT) Animals Biological and medical sciences Coumarins - isolation & purification Coumarins - pharmacology Diacylglycerol O-Acyltransferase - antagonists & inhibitors Diterpenes - isolation & purification Diterpenes - pharmacology General pharmacology hypertriglyceridemia Inhibitory Concentration 50 Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology obesity Pachydictyon coriaceum Phaeophyceae - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Rats, Sprague-Dawley terpenoids type 2 diabetes
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Zusammenfassung:	The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC50 values of 46.0 μm and 23.3 μm, respectively. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.3391