Experimental pharmacokinetics of biologically active plant phenolic compounds. III. Pharmacokinetics of dihydroquercetin

The pharmacokinetics of dihydroquercetin (DHQ) was studied by HPLC in rats after intravenous injection of the compound in single doses of 1,3, 10 and 30 mg/kg and after oral administration in single doses of 50 and 500 mg/kg. Nonlinear pharmacokinetic behaviour was demonstrated for DHQ when administered intravenously to rats; after oral administration DHQ can be detected in blood plasma only in trace amounts. Model independent parameters for intravenous administration of DHQ were calculated, and the description of the dynamics of the change in concentration of DHQ as a two‐compartmental model were given for blood plasma.