Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat

The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin phar...

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Veröffentlicht in:Phytotherapy research 1992-11, Vol.6 (6), p.332-334
Hauptverfasser: Geodakyan, S.V, Voskoboinikova, I.V, Tjukavkina, N.A, Kolhir, V.K, Kolesnik, Y.A, Zjuzin, V.A, Glyzin, V.I, Sokolov, S.J
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container_end_page 334
container_issue 6
container_start_page 332
container_title Phytotherapy research
container_volume 6
creator Geodakyan, S.V
Voskoboinikova, I.V
Tjukavkina, N.A
Kolhir, V.K
Kolesnik, Y.A
Zjuzin, V.A
Glyzin, V.I
Sokolov, S.J
description The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin pharmacokinetics for the above dose levels was nonlinear, and within each dose could be described by a two‐compartmental model. Its nonlinearity might be associated with saturated binding and metabolism of the compound.
doi_str_mv 10.1002/ptr.2650060611
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subjects 2-c-D-glucopyranosil-1
2‐c‐D‐glucopyranosil‐1,3,6,7‐tetrahydroxyxanthon
7-tetrahydroxyxanthon
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Hedysarum alpinum
Hedysarum alpinum L
mangiferin
Medical sciences
pharmacokinetics
pharmacokinetics in rats
Pharmacology. Drug treatments
phenolic compounds
rats
title Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat
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