Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat
The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin phar...
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Veröffentlicht in: | Phytotherapy research 1992-11, Vol.6 (6), p.332-334 |
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creator | Geodakyan, S.V Voskoboinikova, I.V Tjukavkina, N.A Kolhir, V.K Kolesnik, Y.A Zjuzin, V.A Glyzin, V.I Sokolov, S.J |
description | The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin pharmacokinetics for the above dose levels was nonlinear, and within each dose could be described by a two‐compartmental model. Its nonlinearity might be associated with saturated binding and metabolism of the compound. |
doi_str_mv | 10.1002/ptr.2650060611 |
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Its nonlinearity might be associated with saturated binding and metabolism of the compound.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2650060611</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>2-c-D-glucopyranosil-1 ; 2‐c‐D‐glucopyranosil‐1,3,6,7‐tetrahydroxyxanthon ; 7-tetrahydroxyxanthon ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Hedysarum alpinum ; Hedysarum alpinum L ; mangiferin ; Medical sciences ; pharmacokinetics ; pharmacokinetics in rats ; Pharmacology. 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I. Pharmacokinetics of mangiferin in the rat</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin pharmacokinetics for the above dose levels was nonlinear, and within each dose could be described by a two‐compartmental model. Its nonlinearity might be associated with saturated binding and metabolism of the compound.</description><subject>2-c-D-glucopyranosil-1</subject><subject>2‐c‐D‐glucopyranosil‐1,3,6,7‐tetrahydroxyxanthon</subject><subject>7-tetrahydroxyxanthon</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Hedysarum alpinum</subject><subject>Hedysarum alpinum L</subject><subject>mangiferin</subject><subject>Medical sciences</subject><subject>pharmacokinetics</subject><subject>pharmacokinetics in rats</subject><subject>Pharmacology. 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I. Pharmacokinetics of mangiferin in the rat</title><author>Geodakyan, S.V ; Voskoboinikova, I.V ; Tjukavkina, N.A ; Kolhir, V.K ; Kolesnik, Y.A ; Zjuzin, V.A ; Glyzin, V.I ; Sokolov, S.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3591-e6d8d0972524099cb935f4cf9f5e0efd10def98b37b53403ec84c1289f323c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>2-c-D-glucopyranosil-1</topic><topic>2‐c‐D‐glucopyranosil‐1,3,6,7‐tetrahydroxyxanthon</topic><topic>7-tetrahydroxyxanthon</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Hedysarum alpinum</topic><topic>Hedysarum alpinum L</topic><topic>mangiferin</topic><topic>Medical sciences</topic><topic>pharmacokinetics</topic><topic>pharmacokinetics in rats</topic><topic>Pharmacology. Drug treatments</topic><topic>phenolic compounds</topic><topic>rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geodakyan, S.V</creatorcontrib><creatorcontrib>Voskoboinikova, I.V</creatorcontrib><creatorcontrib>Tjukavkina, N.A</creatorcontrib><creatorcontrib>Kolhir, V.K</creatorcontrib><creatorcontrib>Kolesnik, Y.A</creatorcontrib><creatorcontrib>Zjuzin, V.A</creatorcontrib><creatorcontrib>Glyzin, V.I</creatorcontrib><creatorcontrib>Sokolov, S.J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geodakyan, S.V</au><au>Voskoboinikova, I.V</au><au>Tjukavkina, N.A</au><au>Kolhir, V.K</au><au>Kolesnik, Y.A</au><au>Zjuzin, V.A</au><au>Glyzin, V.I</au><au>Sokolov, S.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>1992-11</date><risdate>1992</risdate><volume>6</volume><issue>6</issue><spage>332</spage><epage>334</epage><pages>332-334</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin pharmacokinetics for the above dose levels was nonlinear, and within each dose could be described by a two‐compartmental model. Its nonlinearity might be associated with saturated binding and metabolism of the compound.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/ptr.2650060611</doi><tpages>3</tpages></addata></record> |
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subjects | 2-c-D-glucopyranosil-1 2‐c‐D‐glucopyranosil‐1,3,6,7‐tetrahydroxyxanthon 7-tetrahydroxyxanthon Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Hedysarum alpinum Hedysarum alpinum L mangiferin Medical sciences pharmacokinetics pharmacokinetics in rats Pharmacology. Drug treatments phenolic compounds rats |
title | Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat |
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