Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat

The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin phar...

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Veröffentlicht in:	Phytotherapy research 1992-11, Vol.6 (6), p.332-334
Hauptverfasser:	Geodakyan, S.V, Voskoboinikova, I.V, Tjukavkina, N.A, Kolhir, V.K, Kolesnik, Y.A, Zjuzin, V.A, Glyzin, V.I, Sokolov, S.J
Format:	Artikel
Sprache:	eng
Schlagworte:	2-c-D-glucopyranosil-1 2‐c‐D‐glucopyranosil‐1,3,6,7‐tetrahydroxyxanthon 7-tetrahydroxyxanthon Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Hedysarum alpinum Hedysarum alpinum L mangiferin Medical sciences pharmacokinetics pharmacokinetics in rats Pharmacology. Drug treatments phenolic compounds rats
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Zusammenfassung:	The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin pharmacokinetics for the above dose levels was nonlinear, and within each dose could be described by a two‐compartmental model. Its nonlinearity might be associated with saturated binding and metabolism of the compound.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.2650060611