novel cytotoxic lignan from Seseli annuum L

A new tetrahydrofuranoid lignan named seselinone was isolated from the aerial parts of Seseli annuum, together with three known lignans (eudesmin, magnone A and hernone) and prenylated coumarin umbelliprenin. Seselinone and eudesmin showed cytotoxic activity against C6 rat glioma cell cultures. Copy...

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Veröffentlicht in:	Phytotherapy research 2007-08, Vol.21 (8), p.790-792
Hauptverfasser:	Vučković, Ivan, Trajković, Vladimir, Macura, Slobodan, Tešević, Vele, Janaćković, Ped̄a, Milosavljević, Slobodan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - toxicity Apiaceae - chemistry Biological and medical sciences Cell Line, Tumor cytotoxicity eudesmin General pharmacology Glioma - pathology lignans Lignans - chemistry Lignans - toxicity Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Components, Aerial - chemistry Rats Seseli annuum seselinone
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Zusammenfassung:	A new tetrahydrofuranoid lignan named seselinone was isolated from the aerial parts of Seseli annuum, together with three known lignans (eudesmin, magnone A and hernone) and prenylated coumarin umbelliprenin. Seselinone and eudesmin showed cytotoxic activity against C6 rat glioma cell cultures. Copyright © 2007 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.2152