Identification and properties of 2,5-Dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots

2,5‐Dihydroxy‐4,3′‐di(β‐d‐glucopyranosyloxy)‐trans‐stilbene was identified from Morus bombycis Koidzumi roots. The 2,5‐dihydroxy‐4,3′‐di(β‐d‐glucopyranosyloxy)‐trans‐stilbene at a dose of 400–600 mg/kg had hepatoprotective activity comparable to the standard agent, silymarin. The biochemical assays were confirmed by histological observations showing that the 2,5‐dihydroxy‐4,3′‐di(β‐d‐glucopyranosyloxy)‐trans‐stilbene from Morus bombycis Koidzumi roots decreased cell ballooning in response to CCl4 treatment. These results demonstrate that the 2,5‐dihydroxy‐4,3′‐di(β‐d‐glucopyranosyloxy)‐trans‐stilbene component has a liver protective action against CCl4‐induced hepatotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.