The hepatoprotective activity of kinsenoside from Anoectochilus formosanus

Carbon tetrachloride (CCl4) causes chronic hepatitis, featuring an increase in hepatic hydroxyproline, spleen weight and serum GPT levels and a decrease in plasma albumin levels. Crude extracts of fresh whole plants of Anoectochilus formosanus showed inhibition of chronic hepatitis induced by CCl4 i...

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Veröffentlicht in:	Phytotherapy research 2007-01, Vol.21 (1), p.58-61
Hauptverfasser:	Wu, Jin-Bin, Lin, Wei-Lii, Hsieh, Chang-Chi, Ho, Hui-Ya, Tsay, Hsin-Sheng, Lin, Wen-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives Animals Anoectochilus formosanus Biological and medical sciences Carbon Tetrachloride Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - prevention & control General pharmacology kinsenoside Lethal Dose 50 liver disease Male Medical sciences Mice Monosaccharides - administration & dosage Monosaccharides - chemistry Monosaccharides - pharmacology Monosaccharides - therapeutic use Orchidaceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Protective Agents - administration & dosage Protective Agents - pharmacology Protective Agents - therapeutic use
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Zusammenfassung:	Carbon tetrachloride (CCl4) causes chronic hepatitis, featuring an increase in hepatic hydroxyproline, spleen weight and serum GPT levels and a decrease in plasma albumin levels. Crude extracts of fresh whole plants of Anoectochilus formosanus showed inhibition of chronic hepatitis induced by CCl4 in mice. Bioactivity‐guided fractionation and spectroscopic analysis revealed that kinsenoside was the most active compound. In an in vitro study, the LD50 values for H2O2‐induced cytotoxicity in BALB/c normal liver cells were significantly higher after kinsenoside pretreatment than after vehicle alone, further confirming that kinsenoside shows significant antihepatotoxic activity. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.2025