Trypsin inhibitory effect of wedelolactone and demethylwedelolactone

Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC50 values of WL and DWL were found to be 2.9 and 3.0 µg/mL respectively. Copyright © 2003 John Wiley & Sons, Ltd.

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Veröffentlicht in:	Phytotherapy research 2003-04, Vol.17 (4), p.420-421
Hauptverfasser:	Syed, Samiulla D., Deepak, Mundkinajeddu, Yogisha, Shivanna, Chandrashekar, Arun P., Muddarachappa, Keerthi A., D'Souza, Prashanth, Agarwal, Amit, Venkataraman, B. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chickens Coumarins - pharmacology demethylwedelolactone Eclipta Eclipta alba General pharmacology Humans Inhibitory Concentration 50 Medical sciences Ovum - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Protease Inhibitors - pharmacology Trypsin - drug effects trypsin inhibition wedelolactone
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Beschreibung
Zusammenfassung:	Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC50 values of WL and DWL were found to be 2.9 and 3.0 µg/mL respectively. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1153