Secoiridoid glucosides with free radical scavenging activity from the leaves of Syringa dilatata

Activity‐guided fractionation of the EtOAc and MeOH extract of the leaves of Syringa dilatata NAKAI furnished one free radical scavenger, the secoiridoid glucoside oleuropein together with ligstroside and an iridoid glucoside, syringopicroside. Oleuropein interacted with the stable free radical, 1,1...

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Veröffentlicht in:	Phytotherapy research 2003-04, Vol.17 (4), p.417-419
Hauptverfasser:	Oh, Hyuncheol, Ko, Eun-Kyoung, Kim, Do-Hoon, Jang, Kyu-Kwan, Park, Sung-Eun, Lee, Ho-Sub, Kim, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biphenyl Compounds Chromatography, High Pressure Liquid free radical scavenger Free Radical Scavengers - chemistry General pharmacology Humans Inhibitory Concentration 50 Iridoids - chemistry Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Picrates - chemistry Plant Extracts - chemistry Plant Leaves secoiridoid Syringa Syringa dilatata
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Zusammenfassung:	Activity‐guided fractionation of the EtOAc and MeOH extract of the leaves of Syringa dilatata NAKAI furnished one free radical scavenger, the secoiridoid glucoside oleuropein together with ligstroside and an iridoid glucoside, syringopicroside. Oleuropein interacted with the stable free radical, 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), and showed an IC50 value of 40.4 µM. L‐Ascorbic acid as a positive control showed an IC50 value of 50.3 µM. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1148