Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression

BACKGROUND The role of the bone morphogenetic protein (BMP) pathway in prostate cancer (PC) is unclear. This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Prostate 2004-05, Vol.59 (3), p.234-242
Hauptverfasser: Horvath, Lisa G., Henshall, Susan M., Kench, James G., Turner, Jennifer J., Golovsky, David, Brenner, Phillip C., O'Neill, Gordon F., Kooner, Raji, Stricker, Phillip D., Grygiel, John J., Sutherland, Robert L.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biological and medical sciences
BMP2
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins - biosynthesis
Cell Transformation, Neoplastic
Cohort Studies
Disease Progression
DNA-Binding Proteins - biosynthesis
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Gynecology. Andrology. Obstetrics
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Phenotype
Prognosis
prostate cancer
Prostatectomy
Prostatic Hyperplasia - genetics
Prostatic Hyperplasia - pathology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
radical prostatectomy
Signal Transduction
Smad4
Smad4 Protein
Smad8
Smad8 Protein
Trans-Activators - biosynthesis
Transforming Growth Factor beta
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:BACKGROUND The role of the bone morphogenetic protein (BMP) pathway in prostate cancer (PC) is unclear. This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings with progression to PC. METHODS Radical prostatectomy (RP) specimens from 74 patients with clinically localized PC (median follow‐up 51 months, range 15–152), 44 benign prostatic hypertrophy (BPH) lesions, and 4 normal prostates (NPs) were assessed for BMP2, Smad8, and Smad4 expression using immunohistochemistry. RESULTS Both BMP2 (P 
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.10361