pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T 1 MRI Contrast by Her2-Targeting

pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T 1 MRI Contrast by Her2-Targeting

comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and Gd -based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellula...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Particle & particle systems characterization 2013-09, Vol.30 (9), p.770-774
Hauptverfasser: Hong, Bong Jin, Swindell, Elden P, Macrenaris, Keith W, Hankins, Patrick L, Chipre, Anthony J, Mastarone, Daniel J, Ahn, Richard W, Meade, Thomas J, O'Halloran, Thomas V, Nguyen, Sonbinh T
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and Gd -based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular Gd -uptake in comparison with clinically approved DOTA-Gd , leading to significant MRI contrast enhancement.
ISSN:0934-0866
1521-4117
DOI:10.1002/ppsc.201300158