Front Cover: Translating Immunopeptidomics to Immunotherapy‐Decision‐Making for Patient and Personalized Target Selection

DOI: 10.1002/pmic.201700284 Translation from immunopeptidomics to HLA peptide target to TCR lead to cancer immunotherapy. Cancer antigen Ag007‐01 (blue) bound to HLA‐A*02:01 (red) recognized by ACTengine™ IMA201 T‐cell receptor (green) is currently investigated in ACT trial NCT03247309. Ag007‐01 is...

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Veröffentlicht in:	Proteomics (Weinheim) 2018-06, Vol.18 (12), p.n/a
Hauptverfasser:	Fritsche, Jens, Rakitsch, Barbara, Hoffgaard, Franziska, Römer, Michael, Schuster, Heiko, Kowalewski, Daniel J., Priemer, Martin, Stos‐Zweifel, Vlatka, Hörzer, Helen, Satelli, Arun, Sonntag, Annika, Goldfinger, Valentina, Song, Colette, Mahr, Andrea, Ott, Martina, Schoor, Oliver, Weinschenk, Toni
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Zusammenfassung:	DOI: 10.1002/pmic.201700284 Translation from immunopeptidomics to HLA peptide target to TCR lead to cancer immunotherapy. Cancer antigen Ag007‐01 (blue) bound to HLA‐A*02:01 (red) recognized by ACTengine™ IMA201 T‐cell receptor (green) is currently investigated in ACT trial NCT03247309. Ag007‐01 is detected on squamous NSCLC by LC‐MS/MS shown as heatmap (m/z vs retention time). This is reported in article number 1700284 by Fritsche et al. TCR homology model (Modeller, UCSF) and peptide‐MHC crystal structure rendered with Chimera (UCSF) by Mathias Ferber.
ISSN:	1615-9853 1615-9861
DOI:	10.1002/pmic.201870101