A directed binding model of motor protein motion on protein filaments
We propose a new mechanism of motor protein motion on protein filaments, treating the heads as extended objects connected by an elastic neck linker region. In our model, ATP hydrolysis provides chemical energy while directed binding is key in force generation coupled with an elastic neck linker regi...
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| Veröffentlicht in: | Proceedings in applied mathematics and mechanics 2007-12, Vol.7 (1), p.1030807-1030808 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | We propose a new mechanism of motor protein motion on protein filaments, treating the heads as extended objects connected by an elastic neck linker region. In our model, ATP hydrolysis provides chemical energy while directed binding is key in force generation coupled with an elastic neck linker region storing elastic energy. Simulations of the differential equation of motion, based on this model, agree with experiment for both kinesin and its analog, Ncd, and can also be applied to myosin. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
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| ISSN: | 1617-7061 1617-7061 |
| DOI: | 10.1002/pamm.200700944 |