Safety margin at single neuromuscular junctions
Jitter measurement with axonal microstimulation was used to study synaptic function at 115 neuromuscular junctions (NMJs) of normal subjects at various stimulation rates. Jitter was lowest at 0.5 Hz; it increased slightly at 1, 2, and 5 Hz and remained at that level at 10 Hz (a light work load) and...
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| Veröffentlicht in: | Muscle & nerve 2002, Vol.25 (S11), p.S21-S27 |
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| container_issue | S11 |
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| container_title | Muscle & nerve |
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| creator | Trontelj, Jože V. Mihelin, Marjan Khuraibet, Adnan |
| description | Jitter measurement with axonal microstimulation was used to study synaptic function at 115 neuromuscular junctions (NMJs) of normal subjects at various stimulation rates. Jitter was lowest at 0.5 Hz; it increased slightly at 1, 2, and 5 Hz and remained at that level at 10 Hz (a light work load) and 20 Hz (a heavy work load); and it increased further at 50 Hz (an extreme load). This pattern was seen for the majority of the NMJs, suggesting a high safety factor of neuromuscular transmission maintained rather uniformly over a wide range of discharge rates. A proportion of the normal NMJs had relatively large jitter; these tended to show prominent facilitation as the rate was raised from 5 or 10 to 20 Hz. Similar but more dramatic facilitation improving the safety factor was seen at most NMJs in myasthenia, which was studied for comparison. Such facilitation was not found at normal NMJs with low jitter. © 2002 Wiley Periodicals, Inc. Muscle Nerve Supplement 11: S21–S27, 2002 |
| doi_str_mv | 10.1002/mus.10143 |
| format | Article |
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Jitter was lowest at 0.5 Hz; it increased slightly at 1, 2, and 5 Hz and remained at that level at 10 Hz (a light work load) and 20 Hz (a heavy work load); and it increased further at 50 Hz (an extreme load). This pattern was seen for the majority of the NMJs, suggesting a high safety factor of neuromuscular transmission maintained rather uniformly over a wide range of discharge rates. A proportion of the normal NMJs had relatively large jitter; these tended to show prominent facilitation as the rate was raised from 5 or 10 to 20 Hz. Similar but more dramatic facilitation improving the safety factor was seen at most NMJs in myasthenia, which was studied for comparison. Such facilitation was not found at normal NMJs with low jitter. © 2002 Wiley Periodicals, Inc. Muscle Nerve Supplement 11: S21–S27, 2002</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.10143</identifier><identifier>PMID: 12116282</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Biological and medical sciences ; Electric Stimulation ; Electrodiagnosis. Electric activity recording ; Electrophysiology - methods ; Electrophysiology - standards ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; jitter ; Medical sciences ; Middle Aged ; myasthenia gravis ; Nervous system ; Neuromuscular Junction - physiology ; neuromuscular transmission ; Presynaptic Terminals - physiology ; Reference Values ; safety factor ; stimulation single-fiber electromyography ; Synaptic Transmission - physiology</subject><ispartof>Muscle & nerve, 2002, Vol.25 (S11), p.S21-S27</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3583-50a546bb999cefede8944776553cc867558ab6e83b523fe56bb48a026e6ed69f3</citedby><cites>FETCH-LOGICAL-c3583-50a546bb999cefede8944776553cc867558ab6e83b523fe56bb48a026e6ed69f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.10143$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.10143$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,4012,27906,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13708875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12116282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trontelj, Jože V.</creatorcontrib><creatorcontrib>Mihelin, Marjan</creatorcontrib><creatorcontrib>Khuraibet, Adnan</creatorcontrib><title>Safety margin at single neuromuscular junctions</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Jitter measurement with axonal microstimulation was used to study synaptic function at 115 neuromuscular junctions (NMJs) of normal subjects at various stimulation rates. Jitter was lowest at 0.5 Hz; it increased slightly at 1, 2, and 5 Hz and remained at that level at 10 Hz (a light work load) and 20 Hz (a heavy work load); and it increased further at 50 Hz (an extreme load). This pattern was seen for the majority of the NMJs, suggesting a high safety factor of neuromuscular transmission maintained rather uniformly over a wide range of discharge rates. A proportion of the normal NMJs had relatively large jitter; these tended to show prominent facilitation as the rate was raised from 5 or 10 to 20 Hz. Similar but more dramatic facilitation improving the safety factor was seen at most NMJs in myasthenia, which was studied for comparison. Such facilitation was not found at normal NMJs with low jitter. © 2002 Wiley Periodicals, Inc. Muscle Nerve Supplement 11: S21–S27, 2002</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electrophysiology - methods</subject><subject>Electrophysiology - standards</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>jitter</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myasthenia gravis</subject><subject>Nervous system</subject><subject>Neuromuscular Junction - physiology</subject><subject>neuromuscular transmission</subject><subject>Presynaptic Terminals - physiology</subject><subject>Reference Values</subject><subject>safety factor</subject><subject>stimulation single-fiber electromyography</subject><subject>Synaptic Transmission - physiology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1j81OwzAQhC0EoqVw4AVQLhw4hNpx_HeECgqiBaFS4GY57qZKSdPKTgR9ewwpcOK0q9U3szMIHRN8TjBO-svGh4WkdAd1CVYiTpmSu6gbTjLmVL120IH3C4wxkVzsow5JCOGJTLqoPzE51Jtoady8qCJTR76o5iVEFTRuFYxtUxoXLZrK1sWq8odoLzelh6Pt7KHp9dXT4CYePQxvBxej2FImacywYSnPMqWUhRxmIFWaCsEZo9aGDIxJk3GQNGMJzYEFNJUGJxw4zLjKaQ-dtb7Wrbx3kOu1K0LIjSZYf5XWIZv-Lh3Yk5ZdN9kSZn_ktmUATreA8daUuTOVLfwfRwWWUrDA9VvuvShh8_9HPZ5Ofl7HraLwNXz8Kox701xQwfTL_VDfjS_Vc_LINKWf9398jQ</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Trontelj, Jože V.</creator><creator>Mihelin, Marjan</creator><creator>Khuraibet, Adnan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2002</creationdate><title>Safety margin at single neuromuscular junctions</title><author>Trontelj, Jože V. ; Mihelin, Marjan ; Khuraibet, Adnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3583-50a546bb999cefede8944776553cc867558ab6e83b523fe56bb48a026e6ed69f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electrophysiology - methods</topic><topic>Electrophysiology - standards</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>jitter</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myasthenia gravis</topic><topic>Nervous system</topic><topic>Neuromuscular Junction - physiology</topic><topic>neuromuscular transmission</topic><topic>Presynaptic Terminals - physiology</topic><topic>Reference Values</topic><topic>safety factor</topic><topic>stimulation single-fiber electromyography</topic><topic>Synaptic Transmission - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trontelj, Jože V.</creatorcontrib><creatorcontrib>Mihelin, Marjan</creatorcontrib><creatorcontrib>Khuraibet, Adnan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trontelj, Jože V.</au><au>Mihelin, Marjan</au><au>Khuraibet, Adnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety margin at single neuromuscular junctions</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2002</date><risdate>2002</risdate><volume>25</volume><issue>S11</issue><spage>S21</spage><epage>S27</epage><pages>S21-S27</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Jitter measurement with axonal microstimulation was used to study synaptic function at 115 neuromuscular junctions (NMJs) of normal subjects at various stimulation rates. Jitter was lowest at 0.5 Hz; it increased slightly at 1, 2, and 5 Hz and remained at that level at 10 Hz (a light work load) and 20 Hz (a heavy work load); and it increased further at 50 Hz (an extreme load). This pattern was seen for the majority of the NMJs, suggesting a high safety factor of neuromuscular transmission maintained rather uniformly over a wide range of discharge rates. A proportion of the normal NMJs had relatively large jitter; these tended to show prominent facilitation as the rate was raised from 5 or 10 to 20 Hz. Similar but more dramatic facilitation improving the safety factor was seen at most NMJs in myasthenia, which was studied for comparison. Such facilitation was not found at normal NMJs with low jitter. © 2002 Wiley Periodicals, Inc. Muscle Nerve Supplement 11: S21–S27, 2002</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12116282</pmid><doi>10.1002/mus.10143</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Electric Stimulation Electrodiagnosis. Electric activity recording Electrophysiology - methods Electrophysiology - standards Humans Investigative techniques, diagnostic techniques (general aspects) jitter Medical sciences Middle Aged myasthenia gravis Nervous system Neuromuscular Junction - physiology neuromuscular transmission Presynaptic Terminals - physiology Reference Values safety factor stimulation single-fiber electromyography Synaptic Transmission - physiology |
| title | Safety margin at single neuromuscular junctions |
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