1 H and 13 C NMR spectral assignment of N , N ′‐disubstituted thiourea and urea derivatives active against nitric oxide synthase

The 1 H and 13 C NMR resonances of seventeen N ‐alkyl and aryl‐ N ′‐[3‐hydroxy‐3‐(2‐nitro‐5‐substitutedphenyl)propyl]‐thioureas and ureas ( 1–17 ), and seventeen N ‐alkyl or aryl‐ N ′‐[3‐(2‐amino‐5‐substitutedphenyl)‐3‐hydroxypropyl]‐thioureas and ureas ( 18–34 ), designed as NOS inhibitors, were assigned completely using the concerted application of one‐ and two‐dimensional experiments (DEPT, HSQC and HMBC). NOESY studies confirm the preferred conformation of these compounds. Copyright © 2016 John Wiley & Sons, Ltd.