Analyses of the 500 MHz 1 H spectra of the 3‐Methyl ethers of estrone, estradiol and their 14α‐methyl analogues

The 500 MHz 1 H spectra of the 3‐methyl ethers of estrone, estradiol and their 14α‐methyl analogues were assigned by proton decoupling and analysed by second‐order calculations for chemical shifts and coupling constants. Introduction of a 14α‐Me group effects consistent deshielding of 1,3 diaxially disposed protons. Coupling constant values show characteristic changes for ring D protons, and suggest that some minor perturbation in the H‐9α, ‐11α, ‐11β region is caused by the additional methyl group.