1 H, 3 H and 13 C NMR studies on porphobilinogen

1 H, 3 H and 13 C NMR studies on porphobilinogen

A key intermediate in porphyrin and corrin biosynthesis is the trisubstituted pyrrole porphobilinogen (PBG). The fate of PBG in the biosynthesis of porphyrins and corrins has been monitored by NMR spectroscopy in vivo and in vitro employing various nuclei. The syntheses of highly tritiated PBG and i...

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Veröffentlicht in:Magnetic resonance in chemistry 1985-11, Vol.23 (11), p.939-944
Hauptverfasser: Evans, J. N. S., Fagerness, P. E., Mackenzie, N. E., Scott, A. I.
Format: Artikel
Sprache:eng
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Zusammenfassung:A key intermediate in porphyrin and corrin biosynthesis is the trisubstituted pyrrole porphobilinogen (PBG). The fate of PBG in the biosynthesis of porphyrins and corrins has been monitored by NMR spectroscopy in vivo and in vitro employing various nuclei. The syntheses of highly tritiated PBG and its immediate precursor 5‐aminolevulinic acid (ALA) are reported, together with 3 H, 1 H and 13 C assignments.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.1260231112