Front Cover: Syringaresinol Protects against Type 1 Diabetic Cardiomyopathy by Alleviating Inflammation Responses, Cardiac Fibrosis, and Oxidative Stress

Mol. Nutr. Food Res. 2020, 64, 2000231 DOI: 10.1002/mnfr.202000231 This study mainly demonstrated the cardiac protecting effect of syringaresinol against DCM and its potential mechanisms. Administration of syringaresinol could attenuate hyperglycemia‐induced inflammation, fibrosis and oxidative stre...

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Veröffentlicht in:Molecular nutrition & food research 2020-09, Vol.64 (18), p.n/a
Hauptverfasser: Li, Guangru, Yang, Lei, Feng, Lifeng, Yang, Jiu, Li, Yafei, An, Jiale, Li, Dihua, Xu, Yang, Gao, Yang, Li, Jing, Liu, Jie, Yang, Liang, Qi, Zhi
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Sprache:eng
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Zusammenfassung:Mol. Nutr. Food Res. 2020, 64, 2000231 DOI: 10.1002/mnfr.202000231 This study mainly demonstrated the cardiac protecting effect of syringaresinol against DCM and its potential mechanisms. Administration of syringaresinol could attenuate hyperglycemia‐induced inflammation, fibrosis and oxidative stress and improve cardiac dysfunction. This protective effect might through prevention the invasion of immune cells and suppression of TGF‐β/Smad signaling pathway as well as activation of antioxidant Nrf‐2 system. This is reported by Guangru Li, Lei Yang, Lifeng Feng, Jiu Yang, Yafei Li, Jiale An, Dihua Li, Yang Xu, Yang Gao, Jing Li, Jie Liu, Liang Yang, and Zhi Qi in article 2000231.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.202070040