Front Cover: Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S‐Equol and Its Consequences for ERα Activation

Mol. Nutr. Food Res. 2020, 64, 1900912 DOI: 10.1002/mnfr.201900912 In article 1900912, Qianrui Wang and co‐workers predict plasma concentrations of daidzein and its gut microbial metabolite, S‐equol, following daidzein ingestion using a PBK model that includes a gut microbial compartment. In vitro anaerobic incubations of rat feces are optimized to derive kinetic parameters of gut microbial metabolism of daidzein to DHD, S‐equol, and O‐DMA, which are used as input for the PBK model.