Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry

Combined liquid chromatography–mass spectrometry using electrospray or atmospheric‐pressure chemical ionization has become an important tool in the quantitative analysis of pesticide residues in various matrices in relation to environmental analysis, food safety, and biological exposure monitoring. One of the major problems in the quantitative analysis using LC–MS is that compound and matrix‐dependent response suppression or enhancement may occur, the so‐called matrix effect. This article reviews issues related to matrix effects, focusing on quantitative pesticide analysis, but also paying attention to expertise with respect to matrix effects acquired in other application areas of LC–MS, especially quantitative bioanalysis in the course of drug development. © 2006 Wiley Periodicals, Inc.