Spezifische Adsorbentien für das Peptidantibiotika synthetisierende Enzymsystem Gramicidin S Synthetase, 1. Darstellung niedermolekularer Spacer‐Ligand‐Verbindungen

Several amide derivatives of phenylalanin and prolin were prepared as spacer/ligand compounds by reaction of unprotected or monoprotected aliphatic and aromatic diamines and monoamines with the succinimido esters of the corresponding N‐protected amino acids. The formation of diacylated aliphatic diamines was fast under normal conditions. In the case of aromatic diamines the presence of a bases is necessary. For the preparation of monoacylated diamines best results were obtained with monoprotected diamines. The acylated diamines were purified by column chromatography or by extraction.