Characterization of an established transplantable adenocarcinoma of the gallbladder in Syrian golden hamster

A carcinoma of the gallbladder was transplantable in Syrian golden hamsters. The tumor was induced by subcutaneous injection of N‐nitrosobis (2‐oxopropyl) amine (BOP) following dissection of the common duct and preparation of a cholecysto‐duodenostomy. The histology revealed a poorly differentiated adenocarcinoma. The tumor was inoculated into the cavity of the gallbladder and subcutaneous tissue of the hamster and was transplantable (uptake rate was 100%). This tumor expressed blood grouprelated antigens, including A, H, and P‐glycoproteins. To our knowledge, this is the first report of carcinoma of the gallbladder transplantable in a laboratory animal. © 1994 Wiley‐Liss, Inc.