Common duct stricture associated with hepatic artery infusion of FUDR

A case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct,...

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Veröffentlicht in:	Journal of surgical oncology 1986-01, Vol.31 (1), p.56-59
1. Verfasser:	Laughlin, Edward H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - secondary Colonic Neoplasms - pathology Common Bile Duct Diseases - chemically induced common duct Constriction, Pathologic - chemically induced Floxuridine - administration & dosage Floxuridine - adverse effects FUDR Hepatic Artery Humans infusion Infusions, Intra-Arterial - adverse effects Liver Neoplasms - drug therapy Liver Neoplasms - secondary Male Middle Aged stricture
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Beschreibung
Zusammenfassung:	A case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct, with the lesion occurring more often than is recognized. A guide is given for the evaluation of the FUDR‐infused patient with suspected nonmalignant duct stricture, and for the methods of alleviating extrahe‐patic blockage in these individuals.
ISSN:	0022-4790 1096-9098
DOI:	10.1002/jso.2930310113