Anticoagulant Sulfuric Acid Esters of Synthetic Polyglucoses

Anticoagulant Sulfuric Acid Esters of Synthetic Polyglucoses

The anticoagulant activity and toxicity of a series of sulfated synthetic polyglucoses were studied. The samples possessed 10-40 per cent the activity of heparin and were 2.5-10 times as toxic as heparin. The results obtained are similar to those reported for other sulfated polysaccharides.

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Veröffentlicht in:Journal of the American Pharmaceutical Association (Scientific ed.) 1956-04, Vol.45 (4), p.223-225
Hauptverfasser: Goldsmith, Dale P.J., Kelley, Kane L., Mushett, Charles W.
Format: Artikel
Sprache:eng
Schlagworte:
Anticoagulants
Glucans
Polysaccharides - pharmacology
Sulfuric Acid Esters
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Beschreibung
Zusammenfassung:The anticoagulant activity and toxicity of a series of sulfated synthetic polyglucoses were studied. The samples possessed 10-40 per cent the activity of heparin and were 2.5-10 times as toxic as heparin. The results obtained are similar to those reported for other sulfated polysaccharides.
ISSN:0095-9553
1930-2304
DOI:10.1002/jps.3030450408